The mechanism of action of a drug does not need to be elucidated for it to be approved by the FDA, it just needs to be safe and effective. This could be accomplished either through a pH-dependent mechanism or in response to something like glutathione which has a much higher concentration in the cytosol: Email Address never made public. Archived from the original on Notify me of new comments via email.
The report produced by the committee calls for sustaining the investments in advanced science and technology that produced America’s innovation economy and the establishment of a National Network of Manufacturing Innovation Institutes. In fact, taking advantage of lower endosomal pH to dissociate nucleic acid carriers is a well-known strategy for facilitating endosomal escape of oligonucleotides. Leave a Reply Cancel reply Enter your comment here But keep in mind that the same gene regulation effect can be seen with multivalent oligonucleotide nanoparticles of varying cores, such as self-assembled micellar structures, e. Notify me of new posts via email.
Email Address never made public. Wrighton on microelectrode devices for electrocatalysis. It assumes it does.
You are commenting using your Twitter account. This could be accomplished either through a pH-dependent mechanism or in response to something like glutathione which has a much higher concentration in the mifkin Let me refine those last sentences: In addition to his academic and research work, Mirkin has been involved in shaping science policy decisions.
Learn how your comment data is processed. In response to your comment above: He also co-chaired the PCAST report titled, “Engage to Excel,” focusing on teaching and engagement issues thesi students who are in their first two years of undergraduate study at R-1, 2 and 4-year institutions, and community colleges.
Chad Mirkin – Wikipedia
Retrieved 21 January Antisense gene regulation cannot happen without the particles going out of the endosomes. If desorption occurs due to breaking of the Au-S bond, there cahd be specificity. The SmartFlare is a minor part of the article.
The author is a journalist working for the magazine, not a practicing scientist.
It seems you are unfamiliar with the literature. Retrieved 24 April The report produced by the committee calls for sustaining the investments in advanced science and technology that produced America’s innovation economy and the establishment of a National Network of Manufacturing Innovation Institutes.
I am not sure if I am repeating a citation that is already been provided in this post but low pH seems to stabilize the S-AuNP bond: You are commenting using mirkkn Facebook account. Mirkin was born November 23,in Phoenix, Arizona. Do the oligonucleotides enter with or without the AuNPs? I agree; edited accordingly.
Notify me of new comments via email. Archived from the original on 14 November He is the founding editor of the nanotechnology journal Smalland he is an associate editor of the Journal of the American Chemical Society.
Do you think I got this cchad
A RESPONSE FROM CHAD MIRKIN’S GROUP [follow up #1/n] | Rapha-z-lab
Given that we are talking about experiments on humans, I would have thought that this is a pretty serious concern. The authors are from Northwestern, i. Reference  correspond to six half a dozen articles, 80a to 80f see below for details and links. Rathmann professor of chemistry, professor of medicine, thesus of materials science and engineeringprofessor of biomedical engineeringand professor of chemical and biological engineering, and director of the International Institute for Nanotechnology and Center for Nanofabrication and Molecular Self-Assembly at Northwestern University.